高度近视在全球的患病率呈上升趋势，已成为严峻的健康挑战。高度近视性白内障作为高度近视最常见的并发症，发病年龄比年龄相关性白内障更早，严重影响患者工作期间的生活质量。由于晶状体核通常较硬，HMC 的手术干预难度较大，因此深入了解其发病机制对开发潜在治疗方法至关重要。

过往“肠脑轴”研究多聚焦于肠道菌群分泌的小分子代谢物，如短酸、神经递质等物质影响脑部疾病发生，而首都医科大学基础医学院张晨/王伟/刘希成教授团队2024年11月在 Cell Metabolism （IF27.7）上发表了题为“Microbiota-derived lysophosphatidylcholine alleviates Alzheimer's disease pathology via ...

Among the other pathways, ferroptosis was notably prominent, and the glutathione metabolism pathway ... RNA was extracted and genes such as GPX4, SLC7A11, FTH1, PTGS2, ACSL4, were quantified by qPCR ...

To investigate the relationship between ALOX15 expression and survival, we assessed changes in key indicators of ferroptosis (mitochondrial morphology, ROS, MDA, and divalent iron) in A549 cells after ...

2024年11月25日，西湖大学邹贻龙研究员、王曦研究员作为通讯作者，在 Cell 期刊发表了题为：ACSL4 and polyunsaturated lipids support metastatic extravasation and ...

2012年，美国哥伦比亚大学Brent Stockwell教授和同事在《细胞》杂志发表了一项重磅论文，他们开创性地提出了铁死亡（ferroptosis）一词。与过去所发现 ...

自2018年成立以来，西湖大学吸引了许多国内外优秀的青年学者及知名科学家的加入，经过短短几年的发展，西湖大学建立了理学院、工学院、生命 ...

The accumulation of lipids in hepatocytes in nonalcoholic fatty liver disease (NAFLD) leads to an increase in reactive oxygen species and changes in the intracellular microenvironment, while ...

Similarly, rifampicin and isoniazid, used to treat tuberculosis, show ferroptosis-like features, such as GPx4 reduction and ACSL4 upregulation, but definitive causal evidence is lacking.