高度近视在全球的患病率呈上升趋势，已成为严峻的健康挑战。高度近视性白内障作为高度近视最常见的并发症，发病年龄比年龄相关性白内障更早，严重影响患者工作期间的生活质量。由于晶状体核通常较硬，HMC 的手术干预难度较大，因此深入了解其发病机制对开发潜在治疗方法至关重要。

过往“肠脑轴”研究多聚焦于肠道菌群分泌的小分子代谢物，如短酸、神经递质等物质影响脑部疾病发生，而首都医科大学基础医学院张晨/王伟/刘希成教授团队2024年11月在 Cell Metabolism （IF27.7）上发表了题为“Microbiota-derived lysophosphatidylcholine alleviates Alzheimer's disease pathology via ...

Numerous investigations showed that tumors exhibit different levels of ferroptosis-related genes and proteins, including ACSL4, arachidonate lipoxygenase 15 (ALOX15), ATP synthase, H+ transporting, ...

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, P.R. China University of the Chinese ...

Objective: Diabetic foot ulcer (DFU) is one of the common complications in patients with diabetes mellitus (DM). In order to find a method to monitor and treat the refractory DFU, the ferroptosis ...

Among the other pathways, ferroptosis was notably prominent, and the glutathione metabolism pathway ... RNA was extracted and genes such as GPX4, SLC7A11, FTH1, PTGS2, ACSL4, were quantified by qPCR ...