Deregulated apoptosis may also be the leading cause of cancer therapy ... using cell lines derived from patients (they used the same concentrations of FasL and TRAIL in all experiments).96 While most ...

The receptor CD95 (also named Fas or apoptosis antigen 1) belongs to the tumor necrosis factor (TNF) receptor superfamily. Its cognate ligand, CD95L, is implicated in immune homeostasis and immune ...

OX40 can also trigger the proliferation of lipid-rich Treg cells in naive mice (168). It has been found that OX40/OX40L signaling occurring in the hepatocellular carcinoma microenvironment may be ...

Anthracyclines can induce an immunogenic variant of apoptosis in tumour cells, thereby eliciting an antitumour immune response that is mediated by dendritic cells and cytotoxic T cells.

Apoptosis is a mechanism of programmed cell death and is essential for development and homeostasis. Cell stress stimulates pro-apoptotic signalling pathways that activate caspase proteases and ...