Apoptosis is dependent on caspase activation, whereas the caspase-independent necrotic signaling pathway remains largely uncharacterized. We show here that Fas kills activated primary T cells ...

Interestingly, transgenic mice that expressed HCV core, E1, E2 and NS2 proteins were resistant to Fas antibody-stimulated apoptosis and lethality, as they inhibited Fas antibody-induced release of ...