Mitochondrial DNA (mtDNA) replication is essential for mitochondrial function. This is carried out by a dedicated DNA polymerase gamma, with 5’–3’ polymerase and 3’–5’ proofreading/ exonuclease ...

近年来，免疫检查点抑制剂（ICI）在结直肠癌尤其是错配修复缺陷（dMMR）/微卫星高度不稳定（MSI-H）的患者中应用广泛，而除了 dMMR/MSI-H 外，在结直肠癌中还有一小部分人群存在非常罕见的超突变，即 POLE/POLD1 ...

Many DNA polymerases also have an additional intrinsic proofreading exonuclease activity. The high accuracy or fidelity of semi-conservative DNA replication is the product of nucleotide template ...

Unveiling how genetic variations lead to phenotypic variations is one of the key questions in evolutionary biology, genetics, and biomedical research. Deep mutational scanning (DMS) technology has ...

Background: Both the mother and the infant are negatively impacted by macrosomia. Macrosomia is three times as common in hyperglycemic mothers as in normal mothers. This study sought to determine why ...