The model also demonstrated its ability to identify important transcription factor binding motifs—that is, short DNA sequences that determine CRE activity—thus providing insights into how ...

Subsequently, GO pathway analysis revealed that DNA methylation might affect the physical properties associated with skin cells through focal adhesion and cellsubstrate junction and was likely to ...

Each ATPase contains a QLQ protein interaction domain (QLQ, blue), a helicase SANT-associated domain (HSA, red), the ATPase/helicase domain (yellow), a SNF2 ATP-coupling (SnAC, orange) domain, two A-T ...

The model also demonstrated its ability to identify important transcription factor binding motifs—that is, short DNA sequences that determine CRE activity—thus providing insights into how specific ...

In yeast, downregulation of the DNA damage checkpoint requires the Srs2 DNA helicase, which removes the ssDNA binding complex RPA and the associated Mec1 checkpoint kinase from DNA, thus dampening ...

Comparison of that ancient DNA with modern human DNA showed that the two species had interbred and that people today still carry the genetic fingerprint of that intermixing. Since then ...

虽然已知 RelB 对基因表达有激活和抑制作用，且可能通过多种机制参与基因调控，但在 RelB 缺陷的患者和小鼠中，其导致自身免疫的具体机制仍不明确。由于 DCs 在自身免疫疾病中作用关键，且 RelB 在健康小鼠和人类 DCs 中高表达，研究人员旨在探究 RelB 在 DCs 中抑制炎症基因表达的具体机制。

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows.