The inhibition of SLC7A11 and cysteine starvation could synergize with trastuzumab to induce ferroptosis. Mechanistically, increased H3K4me3 and decreased DNA methylation enhanced SLC7A11 ...

(E) Joint pathway analysis based on metabolomics and transcriptomics data. (F) Map of essential genes involved with cystine/cysteine metabolism. Upregulated genes in JIMT1 are highlighted in red and ...