Program in Chemical Biology, Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, Oregon 97239, United States ...

Misregulation of protein–protein interactions (PPIs) underlies many diseases ... Finally, we confirmed that the formation of the dual covalent cross-linked PPI by the molecular glues occurred on a ...

Protein–protein interaction networks are the networks of protein complexes formed by biochemical events and/or electrostatic forces and that serve a distinct biological function as a complex.

P2Rank: Protein-ligand binding site prediction from protein structure based on machine learning.

j utilized a switching function that captures an effective interaction range between each amino acid-nucleotide pair within the protein-DNA complex: here γ is the enhanced protein-DNA energy model ...

"Our idea was to engineer an interaction in which a small molecule causes two proteins to come together. Some approaches have focused on screening for such small molecules, but we wanted to design ...

Persistent Link: https://ieeexplore.ieee.org/servlet/opac?punumber=4609443 ...

To overcome these challenges and enhance complementarity exploration and exploitation, this article proposes a dual-dynamic cross-modal interaction network (DDCINet), a novel framework comprising two ...

The mitochondrial proteome encompasses about 1,500 proteins encoded by both the nuclear DNA and the maternally inherited mitochondrial DNA. Mutations in the nuclear or mitochondrial genome, or ...