Chronic infection greatly increases the risk for terminal liver disease. Current therapies rarely achieve a cure due to the refractory nature of an intracellular viral replication intermediate termed ...

Objective The HBV HBx regulatory protein is required for transcription from the covalently closed circular DNA (cccDNA) minichromosome and affects the epigenetic control of both viral and host ...

covalently closed circular DNA (cccDNA) and liver inflammation in chronic hepatitis B (CHB) infection patients. Methods: From August 2013 to June 2022, CHB patients at Hebei Medical University Third ...

导语慢性乙型肝炎（chronichepatitisB，CHB）是由乙型肝炎病毒（hepatitisBvirus，HBV）感染引起的全球重大公共卫生问题，据世卫组织报道，2019年全球约有2.96亿慢性HBV感染者，82万人死于慢性HBV感染导致的肝硬 ...

Chronic hepatitis B virus (HBV) infection imposes a severe burden on global public health. Currently, there are no curative therapies for millions of chronic HBV-infected patients (Lok et al., 2017).

近年来，国内外大量研究均已表明，HBV在肝内形成的共价闭合环状DNA（HBV cccDNA）库的持续存在与HBV慢性持续性感染以及慢性乙型肝炎（CHB）难以治愈 ...

It also provides PBGENE-HBV for the treatment of chronic hepatitis B virus (HBV) to eliminate covalently closed circular DNA with direct cuts and edits as well as to inactivate integrated HBV DNA ...

Circular mammoth-bone structure ... or some other purpose is yet unclear. But now, a new DNA study of 39 bone samples from 30 mammoths from the Kostenki 11 site is offering new clues about ...

Viral hepatitis is a major danger to public health. According to WHO’s 2024 Global Hepatitis Report, viral hepatitis deaths ...

Department of Chemical Sciences and Technologies, University of Rome, Tor Vergata, Via della Ricerca Scientifica, Rome 00133, Italy ...

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DNA polymerases carry out crucial functions in many DNA metabolic processes. Polymerases catalyse the addition, using a template, of complementary nucleotides to the 3′ end of DNA primer strands.