Expression levels of cholesterol 7α-hydroxylase, a key enzyme in bile acid synthesis, were similar in wild-type and ACAT2-deficient mice fed a chow diet and were suppressed in both groups of mice ...

They lower serum LDL-C levels by competitively inhibiting the enzyme HMG-CoA reductase, which transforms HMG-CoA to mevalonate during cholesterol synthesis. (3) However ... United Kingdom). Dodecanoic ...

High cholesterol can increase the risk of heart disease and strokes. The signs are usually not obvious, but sometimes, you ...

Bile acids (BA) affect the HPA axis function in hepatic cholestasis ... along the HPA axis regulates the hepatic functions according to environmental and stress conditions; (ii) metabolic pathways of ...

Free (unconjugated) bile acids were consistently demonstrated in ileal samples, and occasionally in lower jejunal samples, by thin-layer chromatography, supplemented in some cases by gas/liquid ...

More information: Siva Karthik Varanasi et al, Bile acid synthesis impedes tumor-specific T cell responses during liver cancer, Science (2025). DOI: 10.1126/science.adl4100 ...

Results: Untargeted metabolomics revealed that, after SY009 treatment, there were differences in metabolic pathways, including primary bile acid biosynthesis; biosynthesis of unsaturated ... also ...

While studying mouse and human liver tumors, they discovered that certain bile acids in the liver could affect the activity of cancer-fighting immune cells, called T cells. The researchers ...

Scientists seek advanced technologies to better understand these metabolites and their influence on health. Thomas Horvath: Bile acids are cholesterol-derived compounds essential for digesting lipids ...

Reduced receptor-mediated catabolism of LDL causes high plasma LDL cholesterol (LDL-C ... ezetimibe and bile acid sequestrants. In untreated HoFH, coronary heart disease usually develops in ...