This review provides an overview of TLR signaling pathways and their regulators and discusses how TLR signaling, directly and indirectly, regulates cell-mediated immunity. In addition, we also discuss ...

The LNP-mRNA modality is a novel approach that uses lipid nanoparticles to deliver messenger RNA into cells. The mRNA acts as ...

The use of thyroxine replacement therapy can reverse the above process. Therefore, thyroid hormone may be a critical neuroendocrine regulator of tumor evolution, most likely through the regulation of ...

A phase 1 study of a personalized cancer vaccine demonstrated antitumor immunity in all treated patients with resected renal ...

Can immune cells protect your brain? Yes! Tregs act as gatekeepers, controlling inflammation and supporting memory formation ...

Emerging evidence suggests that additional cell-death pathways are crucial for the triggering of inflammation and immunity. To begin to understand the contribution of cell death to immunity ...

Anthracyclines can induce an immunogenic variant of apoptosis in tumour cells, thereby eliciting an antitumour immune response that is mediated by dendritic cells and cytotoxic T cells.

A group of scientists in China has revealed a novel mechanism whereby a short form of IL-18, generated by caspase-3 cleavage ...

Prof. MENG Guangxun's team from the Shanghai Institute of Immunity and Infection of the Chinese Academy of Sciences, and collaborators, have revealed a novel mechanism whereby a short form of IL-18, ...

Scientists from DZNE, University Hospital Bonn (UKB) and the University of Bonn provide new evidence that preventing brain ...

Diet plays a pivotal role in influencing autoimmune diseases like multiple sclerosis (MS), inflammatory bowel disease, and ...

Looking forward, it might also be possible to use T-cell testing for this purpose ... If so, it is discriminatory to treat natural immunity differently to vaccine-mediated immunity, and this is ...