However, the requirement of PPAR-γ for monocytic differentiation and the relative contribution of the PPAR-γ–CD36 pathway to lipid uptake in differentiated macrophages have not been tested.

3Department of Pathology, Yale School of Medicine, New Haven, Connecticut. 4Department of Dermatology, Yale School of Medicine, New Haven, Connecticut. 5Yale Center for Precision Cancer Modeling, Yale ...

These modifications control CD36 expression, maturation and subcellular localization in cells (Luiken et al., 2016). CD36 is expressed in multiple cell types, including platelets, ...

Liver kinase B1 (LKB1) is known to shape the regulation of macrophage function by participating in multiple processes including cell metabolism, growth, and polarization. However, whether LKB1 also ...

Burke Neurological Institute, White Plains, NY (H.J., I.P., K.W.P., J.M., A.M., S.C.). InVitro Cell Research, Englewood, NJ (H.J., J.W.C.). Helen & Robert Appel ...

2 Its specificity for RA is thus limited. Here we describe the mRNA and protein expression of PAD enzymes in monocytes and macrophages, as well as in synovial fluid mononuclear cells (SFMCs). Possible ...

Immunoassays were used to quantify FFA-induced protein secretion. TLR4 signalling was inhibited extracellularly and intracellularly. Fatty acid translocase (CD36), responsible for transporting ...

Although gut microbiota and lipid metabolites have been suggested to be closely associated with type 2 diabetes mellitus (T2DM), the interactions between gut microbiota, ...

kuleuven.be Intestinal resident macrophages are at the front line of host defence at the mucosal barrier within the gastrointestinal tract and have long been known to play a crucial role in the ...

Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, China ...