Cancer immunotherapy has represented a significant advancement in cancer treatment; however, many patients experience relapse or develop resistance to this treatment. Bispecific antibodies that ...

It took less than an hour to realize something had gone terribly wrong. In March 2006, six healthy volunteers of a Phase I clinical trial who had received a single infusion of the CD28 ...

Fig 1. Overview of the CAR-T cell therapy process, highlighting the sequential steps from leukapheresis to CAR-T cell infusion. (1) T cells are isolated from the patient's peripheral blood through ...

Conventionally, the first and second stimulation signals in vitro, simulating the process in vivo, are achieved using anti-CD3 antibody, anti-CD28 antibody, or CD3/CD28 magnetic beads, along with the ...