Tiumbio Co Ltd. has described bromodomain-containing protein 4 (BD2 domain) (BRD4 BD2) inhibitors reported to be useful for the treatment of cancer, fibrosis, diabetes, metabolic syndrome, and renal ...

Commissions do not affect our editors' opinions or evaluations. A custom domain name is your address on the internet. It makes up part of the URL shown at the top of your browser window and lets ...

A detailed breakdown of the pros and cons of registering your domain through your web host, based on my 16 years of building websites. Dianna Gunn built her first WordPress website in 2008.

In this study, we computationally modelled protein complex structures and dynamics associated with a series of PROTACs featuring different linkers to investigate why these PROTACs, all of which formed ...

Commissions do not affect our editors' opinions or evaluations. Outside of the most coveted domain names, your domain name is usually one of the lowest costs of being online. However, how to get a ...

The study further delineates the role of epigenetic readers from the bromoterminal and extraterminal domain (BET) protein family such as Brd2 and Brd4, which recognise and interact with acetylated ...

We may receive compensation when you click on links to products we review. Please view our affiliate disclosure. In the rapidly evolving digital landscape, the significance of having a unique and ...

Ubiquitin-binding domains (UBDs) are modular elements that bind non-covalently to the protein modifier ubiquitin. Specific ubiquitin–UBD interactions are crucial for the regulation of multiple ...

New research has pulled back the curtain on a "deficiency" in Google's "Sign in with Google" authentication flow that exploits a quirk in domain ownership to gain access to sensitive data. "Google's ...

Above all, AMPK increases ULK1 activity by directly phosphorylating Ser467, Ser555, Thr574, and Ser637 at least four sites, which increases the recruitment of autophagy-relevant proteins (ATG proteins ...

Breast cancer (BC) is a kind of malignant cancer in women, and it has become the most diagnosed cancer worldwide since 2020. Histone methylation is a common biological epigenetic modification ...