cGAS can also act as a selective autophagy receptor for micronuclei causing their ultimate degradation and thereby prohibiting them from releasing DNA into the cytosol. Finally, K48-linked ...

The development of targeted protein degraders offers novel strategies for treating cancer and chronic viral infections. This Patent Highlight integrates bifunctional degraders, leveraging autophagy ...

Autophagic flux was examined by the buildup of p62 or ubiquitinated organelle protein. Endolysosomal structures were examined by electron microscopy. Cell-specific autophagy was evaluated by ...

Parkinson’s disease is a brain disorder that affects movement, making everyday tasks difficult for nearly one million people ...

29423120] 20. CUL5-ASB6 Complex Promotes p62/SQSTM1 Ubiquitination and Degradation to Regulate Cell Proliferation and Autophagy.[ PMID: 34164402] 21. Sequestosome 1/p62: A multitasker in the ...

This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

Our results demonstrate that SQ exerts renoprotective effects on renal I/R injury via reducing apoptosis and enhancing autophagy, which are associated with regulating ERK/mTOR pathways. Pierce® BCA ...

Apoptosis and autophagy constitute the two self-destructive processes by which supernumerary, damaged or aged cells and organelles are eliminated. Beyond this homeostatic function, autophagy is ...