Proliferation is probably an early event, followed by a chronic process that provides an essential fibrous cap that prevents plaque rupture. With the recognition of the essential involvement of ...
Abnormal accumulation of apoptotic and necrotic cells resulted in plaque enlargement, necrotic core formation and plaque rupture in AS. Under physiological conditions, apoptotic cells (ACs) could be ...
MAIN OUTCOME MEASURES Histopathological determination of plaque erosion as substrate for acute thrombosis; location and histological type of coronary thrombosis; acute and healed myocardial infarcts; ...
An important mechanism responsible for the sudden and unpredictable onset of acute thrombosis is plaque rupture. [1] The risk of rupture depends more on the plaque's composition rather than its size.
Immune-inflammatory responses play key roles in all phases of the pathology and inflammation contributes to plaque rupture resulting in clinical manifestations such as myocardial infarction (MI) and ...
However, whether LKB1 also affects the functional plasticity of macrophages in atherosclerosis has not attracted much attention. Abnormal macrophage function is a pathophysiological hallmark of ...