Receptors such as EGFR, HER2, MET and ALK interface with common downstream signaling pathways and 'addiction switching' can occur, either by the inhibition of one receptor triggering a switch to ...

These processes are genetically controlled and depend both on the history of cells (lineage) and on the activities of signalling pathways, which coordinate the cell interactions leading to ...

MAPK-ERK pathway: A signaling pathway that regulates various cellular processes, including growth and differentiation, and is often implicated in cancer. ALK inhibitors: Targeted therapies that ...

FDA 2025 pulmonology drug alerts, including drug approvals/warnings, vaccine approvals, and medical device recalls/updates.

In conclusion, this work indicated that psychological stress may down-regulate the miR-335-3p expression, which resulted in the accumulation of FOS and the up-regulation of NFACT1 signaling pathway in ...

1 Day ALK 3.09% DJIA 0.38% S&P 500 0.53% Transportation/Logistics -0.27% ...

Telomerase is reactivated by genomic TERT rearrangements in ∼30% of diagnosed high-risk neuroblastomas. Dismal patient prognosis results if the RAS/MAPK/ALK signaling transduction network also harbors ...

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical ...

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