However, ectopic ACTH production is a distinctive cause of CS with a particular high mortality because the hypercortisolism can be rapidly progressive. Moreover, severe hypertension and hypokalemia ...

Abbreviations: ACTH = adrenocorticotropic hormone; AME = apparent mineralocorticoid excess; CAH = congenital adrenal hyperplasia; DOC = deoxycorticosterone; FH-I = familial hyperaldosteronism type ...

Children with various types of childhood epilepsy that do not respond to the usual seizure medicines may be candidates for treatment with adrenocorticotropic hormone or ACTH. ACTH is a first-line ...

Is your dog suddenly lethargic, losing weight, or vomiting? It could be Addison’s disease! Learn the signs, risks, and ...

The preferred treatment for patients with ACTH-independent bilateral adrenal hyperplasia is bilateral adrenalectomy. While treatment for ectopic tumors targets the underlying neoplasm, patients ...

Mineralocorticoid deficiency induces a rise in serum potassium levels (usually the first sign of salt wasting) and sodium levels fall. Urinary sodium levels will be inappropriately high. Further ...

Lenore Levine and Maria developed data relating baseline and ACTH-stimulated blood levels of 17-hydroxyprogesterone, showing that individuals with nonclassic and classic CAH could be readily ...

Fresh adrenal gland tissues from each group were pooled and washed twice in ice-cold RPMI 1640 medium (GIBCO) containing 0.04% BSA (GIBCO), briefly chopped and then digested using collagenase I (0.2%; ...

5 Furthermore, Src is essential for NALCN activation, 4 potentially explaining the increased 5-HT-induced vasoconstriction observed in DOCASH. The signaling pathway from mineralocorticoids to NALCN ...