相关研究结果于2025年1月1日在线发表在Nature期刊上，论文标题为“Dysregulation of mTOR signalling is a converging mechanism in lissencephaly”。 论文共同通讯作者 ...

Next, researchers analyzed the mTOR signaling-related protein activation in brain regions associated with mood disorders and mapped distinct phosphorylation patterns in the medial prefrontal ...

This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

Overall, the study demonstrated in vitro and in vivo that CePA can spatially block the phosphorylation and activation of mTOR to reduce hepatic steatosis, lipid-related damage, and fibrosis of ...

Our laboratory is dedicated to understanding the consequences of activation of these pathways and to using this information to develop mechanism-based therapeutic strategies. The laboratory is ...