We know today that Wnt and a handful of other signalling systems (Notch, Hedgehog, TGFβ (transforming growth factor-β)–BMP (bone morphogenetic protein) and receptor tyrosine kinases ...

In a paper published March 21, 2013, in the journal Science, Nusse and his collaborators show that a protein called Wnt3a coordinates the orientation of the two different cell types that are generated ...

Scientists have uncovered a key mechanism in jellyfish embryos that provides new insights into how the body plan of these ...

Stem cells hold the secret to regenerating tissue and maintaining youthful features. Yet, certain cells, such as melanocyte stem cells (McSCs), fail earlier than others, leading to visible signs of ...

While researchers know that Wnt proteins help activate the repair process in damaged liver cells, which ones actually control ...

Nusse’s lab at Stanford focuses on a family of proteins of called Wnts, which are key regulators of stem cell fate. To find and follow stem cells in a variety of tissues, they have developed mice in ...

Our focus is on the Src family tyrosine protein kinases, Hedgehog and Wnt proteins. Petrova E, Rios-Esteves J, Ouerfelli O, Glickman JF, Resh MD. Inhibitors of Hedgehog acyltransferase block Sonic ...

We also isolated new zebrafish mutants with affected tail bud and somite development indicative of a defect in signaling system. 5. Wnt signaling protein. We investigated Wnt proteins, a central ...

Wnt signaling refers to a network of proteins that controls processes such as cell differentiation, and is known to play a role in body axis specification. It can be seen as a set of instructions ...

a robust and versatile growth factor designed for improved protein stability and performance for stem cell culture applications. And lastly, Wnt/RSPO1, Wnt/RSPO2 and Wnt/RSPO3 Agonists are key ...