We know today that Wnt and a handful of other signalling systems (Notch, Hedgehog, TGFβ (transforming growth factor-β)–BMP (bone morphogenetic protein) and receptor tyrosine kinases ...

Scientists have uncovered a key mechanism in jellyfish embryos that provides new insights into how the body plan of these ...

In a paper published March 21, 2013, in the journal Science, Nusse and his collaborators show that a protein called Wnt3a coordinates the orientation of the two different cell types that are generated ...

Researchers have discovered that a single molecule, Wnt3, coordinates a two-step process of cell polarity orientation that enables jellyfish embryos to develop around a central axis, shedding light on ...

“Proteins are the body’s own home-made drugs ... Reference: Gurriaran-Rodriguez U, Datzkiw D, Radusky LG, et al. Identification of the Wnt signal peptide that directs secretion on extracellular ...

Stem cells hold the secret to regenerating tissue and maintaining youthful features. Yet, certain cells, such as melanocyte ...

Our focus is on the Src family tyrosine protein kinases, Hedgehog and Wnt proteins. Petrova E, Rios-Esteves J, Ouerfelli O, Glickman JF, Resh MD. Inhibitors of Hedgehog acyltransferase block Sonic ...

We also isolated new zebrafish mutants with affected tail bud and somite development indicative of a defect in signaling system. 5. Wnt signaling protein. We investigated Wnt proteins, a central ...