Luckily for us, ice-nine is fictitious. But its biological counterpart, unfortunately, is not. The misfolded proteins known as prions are very real. Prions are proteinaceous infectious particles, ...

Interestingly, the extended PMCA yielded novel forms of misfolded prions that caused new disease phenotypes. When injected into wild-type hamsters, the PMCA-generated hampster PrP Sc caused ...

A system for the rapid amplification of misfolded prion oligomers provides new evidence supporting the prion hypothesis and may offer a powerful diagnostic tool. The prion hypothesis remains ...