Another COX2 inhibitor, marketed in the European Union for treatment of postoperative pain, is parecoxib, an injectable prodrug of valdecoxib. All COX2 inhibitors undergo oxidative drug metabolism ...

Rofecoxib and valdecoxib have been withdrawn from the market because they increase the risk of cardiovascular events. To determine whether these drugs and other types of selective cyclooxygenase 2 ...

Parecoxib sodium is an amide prodrug of valdecoxib, a novel oral COX-2-specific inhibitor. Parecoxib sodium has no inhibitory activity on either COX-1 or COX-2; all enzyme inhibitory effects are ...

Blood-pressure and cardiovascular-safety data on valdecoxib are, however, limited. While some of the cardiovascular effects of COX2-selective inhibitors might be caused by a prostacyclin and ...

The National Pharmaco Vigilance Advisory Committee has prohibited the sale and manufacture of the drug Valdecoxib, indicated for arthritis and The National Pharmaco Vigilance Advisory Committee ...