Based on early studies, it was hypothesized that expression of Fas ligand (FasL) by tumor cells enabled them to counterattack the immune system, and that transplant rejection could be prevented by ...

However, as tumors evolve, they exploit the TIME to ... thereby influencing processes like immune escape, angiogenesis, and metastasis. HCC is particularly adept at manipulating the TIME via ...

Immunotherapy is based on harnessing a person's own immune system to attack cancer cells. However, patients with certain tumors do not respond to these therapies and it remains unclear why.

Immunotherapy, cancer treatments that alter the immune system, making it better apt to fight tumor cells, have provided novel ...

Many of the cells in the innate immune system produce cytokines or interact with other cells directly to activate the adaptive immune system. In cancer cells, mutations can lead to expression of tumor ...

Immunotherapy is a treatment that strengthens the ability of the patient’s own immune system to detect and destroy cancer. Cancer cells often have mutations that allow them to escape the immune system ...

The group has established a platform to combine the study of human tissue specimens and mouse models of cancer to address key questions ranging from mechanisms of immune escape and treatment failures ...

Much of our knowledge of the protein PD-1, a leading cancer ... to escape the effects of rodent-specific pathogens. "The rodent ancestors survived the extinction event but their immune receptor ...

Yet treatments leveraging PD-1 are only effective in a small fraction of cancer ... escape the effects of rodent-specific pathogens. "The rodent ancestors survived the extinction event but their ...