The kynurenine pathway is a crucial metabolic route for the amino acid tryptophan, leading to the production of several bioactive compounds that play significant roles in immune regulation and ...

While tryptophan is known to be metabolized into several important compounds, including the neurotransmitter serotonin and kynurenine, a precursor of the B vitamin niacin, the study showed that ...

IDO is the rate-limiting enzyme in the tryptophan-to-kynurenine metabolic pathway. Accordingly, metabolomic analysis surveying 458 different metabolites revealed two molecules showing increased ...

We found that one of these traits is a metabolite called kynurenine, which is produced from the breakdown of the amino acid ...