本研究报道了模式识别受体TLR3的微型蛋白结合物的计算设计。当寡聚化时，微小蛋白结合物在细胞中诱导TLR3信号，这表明它们可能是疫苗或传染病或癌症治疗的有用成分。 计算设计新型蛋白激动剂，靶向调控 TLR3 信号通路 在免疫学和药物研发领域，华盛顿大学 ...

Jean-Laurent Casanova and colleagues report in Science a Toll-like receptor 3 (TLR3) deficiency in two children with herpes simplex virus type 1 (HSV1) encephalitis (HSE), and identify autosomal ...

The oligosaccharide responsible for altered signalling was identified. Conclusions HMOSs and 2′-FL directly inhibit LPS-mediated inflammation during ETEC invasion of T84 and H4 IECs through ...