Repeated brain injury resulted in SOD1-ALS mice showing greater weight loss, an earlier tremor in the hind limbs, and ...

Increased expression of wild-type SOD1 in mice with ALS does not slow disease progression or diminish the pathological changes in motor neurons. An alternative set of mechanisms to explain the ...

You have full access to this article via your institution. Figure 1: (a-c) Apoptotic changes are absent in mutant SOD1 mice. Although we cannot definitely rule out that motor neuron death in ...

Immunization is the process of providing specific protection against the most common and damaging pathogens or immunogenic agent in a disease. To orchestrate an immune response, the body first ...

An active immunization protocol using recombinant SOD1 mutant protein was successful in delaying onset of disease and mortality in an ALS mouse model. Passive immunization through intraventricular ...

In a transgenic mouse model of ALS (a motor neuron disease), the treatment significantly lowered levels of the disease-causing gene called Sod1 and its associated protein. Similarly, a different ...