The drug's effect on P-glycoprotein and CYP3A4 is opposite that of ritonavir, acting as an inducer of both. When tipranavir is coadministered with ritonavir, the net effect is P-glycoprotein ...

By contrast, co-administration of metamizole with a potentially 2.9-fold hepatocytic CYP3A4 induction may result in a reduction or loss of nirmatrelvir/ritonavir effectiveness. 3. Accurate dose ...

ritonavir in this combination serves a different purpose. It inhibits the enzyme that metabolizes nirmatrelvir (CYP3A4). As a result, it slows the breakdown of nirmatrelvir, resulting in higher ...

Potentiated by CYP3A4 inhibitors (eg, ritonavir, ritonavir/darunavir, ritonavir/fosamprenavir); adjust ketoconazole dose as needed. Separate dosing of acid neutralizing drugs (eg, aluminum ...