Ribonucleosides such as 5-azacytidine or zebularine are reduced at the diphosphate level by ribonucleotide reductase for incorporation (not shown). Once in DNA, the fraudulent bases form covalent ...

kinetically altered dihydrofolate reductase, increased 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase activity, polymorphic variants) Slow transport via folate receptor (lower ...