Factors found to be amplified in human tumors are indicated in green and those found to be frequently lost are indicated in red. Black lines indicate direct activation (arrowheads) or inhibition ...

Figure 1: a, Sequence alignment of SAM domains from the Eph family of receptor tyrosine kinases and selected ... other protein interaction modules with signaling functions such as SH3, SH2 ...

This manuscript provides a comprehensive overview of potential resistance mutations within MET Receptor Tyrosine Kinase and defines how specific mutations affect different inhibitors and modes of ...

What is the essential forward-grade signaling mechanism used by the receptors that cause vascular mitochondrial fragmentation ... smooth muscle 22 α; and Tie2, tyrosine kinase with immunoglobulin like ...

In this study, we present the successful and clinically relevant use of commercially available phospho-protein arrays for analyses of the phosphorylation profiles of a broad spectrum of receptor ...

Gao Guo is an assistant professor in the UAB Department of Neurosurgery. His research focuses on elucidating the role of receptor tyrosine kinase in the invasion and survival of glioblastoma (GBM). He ...

In this issue of Circulation Research, Wan et al identify the MER tyrosine kinase receptor as an engulfment receptor important for the clearance of cellular debris generated during acute cardiac ...

The FDA has granted Priority Review to nipocalimab for the treatment of antibody positive patients with generalized myasthenia gravis.

Background Tyrosine kinase 2 (Tyk2) is a member of the JAK family that phosphorylates STAT proteins downstream of the IL-12, IL-23 and the Type I interferon receptor. Tyk2 genetic variants have been ...

TIE1, a receptor tyrosine kinase, was found to be upregulated by ... In conclusion, this work has identified a novel signaling pathway involving ING5, TIE1, and PDK1 Y163 phosphorylation that ...

However, disseminated TB in the context of isolated impaired cellular responses to interleukin (IL)-23 due to tyrosine kinase 2 (TYK2) deficiency has been rarely reported. We highlight the case of a ...