Importantly, ManS was produced by a noncanonical biogenesis mechanism: The ribonuclease RNase III, which usually cuts double-stranded RNA, cleaves at a single-stranded region in the mRNA 3'UTR.

"Seeing the RNase Z complex in such detail is like watching ... providing us with invaluable insights into the precise mechanisms of tRNA maturation." One key finding is the discovery of the ...