Protein synthesis is vital for life, translating genetic information from DNA to functional proteins through transcription ...

Promoter sequences are DNA sequences that define where transcription of a gene by RNA polymerase begins. Promoter sequences are typically located directly upstream or at the 5' end of the ...

This polymerase contains four catalytic ... sequences in the DNA), these elements constitute the core promoter. However, changes in RNA pol II affinity and, therefore, gene expression can be ...

DNA transcription is the vital first step needed for switching on our genes. For a gene to be switched on, it must be acted ...

These proteins impart on RNA polymerase the ability both to recognize promoter DNA, and to orchestrate the strand separation that accompanies formation of a transcription-competent RNA ...

Announcing a new publication for Acta Materia Medica journal. Single-cell RNA sequencing (scRNA-seq) data from published datasets were obtained to investigate the expression and dysregulation of ...

RNA polymerase binds to a region just before the gene, called the promoter, before moving down the DNA to the gene. Enhancers are regions of DNA that act as molecular switches for turning genes on or ...

Announcing a new publication for Acta Materia Medica journal. Single-cell RNA sequencing (scRNA-seq) data from published datasets were obtained to investigate the expression and dysregulation of ...

Our mission is to elucidate fundamental mechanisms that control the elongation phase of transcription by RNA polymerase II (Pol II ... dependent kinases which trigger Pol II release from ...