However, it has proved difficult to engineer inhibitors of cysteine, serine or threonine proteases that do not contain an irreversible mechanism-based electrophile. This could be a matter of trial ...

Recent research has focused on understanding the mechanisms behind this drug ... ultimately leading to reduced efficacy of protease inhibitors. One study investigated the M46I mutation in HIV ...

Quoin Pharmaceuticals Ltd. (NASDAQ: QNRX) (the “Company” or “Quoin”), a clinical stage, specialty pharmaceutical company focused on rare and orphan diseases, today announces further clinical evidence ...

Researchers from Kumamoto University have identified a liver-derived protein, serine protease inhibitor A1 (SerpinA1 ... finding reveals a novel signaling mechanism that operates independently ...

Nucleoside reverse transcriptase inhibitor; PI: Protease inhibitor; PK: Pharmacokinetics; RPV: Rilpivirine. Data taken from [10,33–38]. Blake Max's spouse is employed as a regional medical ...