Prions represent a new class of infectious agents which propagate on a protein-only level, not requiring agent-encoded nucleic acids. Newly emergent prion diseases such as bovine spongiform ...

May 17, 2024 — A new study of prion diseases, using a human cerebral organoid model, suggests there is a substantial species barrier preventing transmission of chronic wasting disease (CWD ...

While prion disorders like Creutzfeldt-Jakob disease are vanishingly rare in humans, studying these conditions could provide important insights into more common diseases that involve protein ...

It used to be that prion diseases were novelties — an odd ... and even yeast strains contain proteins that can behave like infectious prions. Given the unique characteristics of prions, new ...

Three broad neuropathogenic mechanisms are proposed ... If so, PrP C contributes to neurotoxicity in prion disease but by uncertain mechnisms.

Researchers have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition. The treatment ...

Prions, which are a special class of proteins, are best known as causative factors for mad cow and other neurodegenerative diseases. Prions, which are a special class of proteins, are best known ...

Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for prion disease that extends lifespan by about 50% in a mouse model of the fatal neurodegenerative ...

In these conditions, the prions misfold into a toxic form and then spread throughout the brain, causing other prion proteins to misfold as well. Some researchers believe that proteins linked to other ...

and Creutzfeldt–Jakob disease (CJD) in humans. In TSEs the normal cellular prion protein (PrP C) is transformed into an infectious disease-associated isoform, PrP Sc — a potential target for ...

preventing harmful aggregation linked to prion diseases. Their in vitro and cell culture models show how these anchors inhibit clumping, offering potential pathways for treatments targeting the ...