Of the three origins of prion diseases—familial, infectious and what is called 'spontaneous'—the latter is most common in humans. In this case, a normal prion protein spontaneously 'flips' to ...

Researchers have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition. The treatment, which uses ...

R esearchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for prion disease that extends lifespan by about 50% in a mouse model of the fatal neurodegenerative ...

There is currently no cure for prion disease, and the new approach could be an important step towards treatments that prevent the disease or slow its progression in patients who have already ...

Viralgen and Axovia Therapeutics are partnering to develop and manufacture a gene therapy for the treatment of retinal ...

this has been termed a 'subversion of function'. If so, PrP C contributes to neurotoxicity in prion disease but by uncertain mechnisms.

and Creutzfeldt–Jakob disease (CJD) in humans. In TSEs the normal cellular prion protein (PrP C) is transformed into an infectious disease-associated isoform, PrP Sc — a potential target for ...

Prion diseases such as CWD ... “Even if the risk was 0.005 percent,” Bradshaw says, “I don’t want to be patient zero.” ...