When the RF stalls, the initial ssDNA signal activates ATR. Once activated, ATR kinase phosphorylates a variety of proteins to induce the replication checkpoint and promote RF stability.

Biologists have identified important components and mechanisms of the molecular machinery that transmits information about a pathogen encounter within the plant organism.

Plant pests such as bacteria and fungi lead to significant yield losses in agriculture. In order to develop new strategies ...

The rate at which DSBs form at stalled forks is greatly increased in cells with defective ATR signalling.

Short for ataxia telangiectasia and Rad3-related kinase, ATR inhibition is also being investigated by rival companies such as AstraZeneca and Bayer in pre-clinical studies. Damage to DNA is the ...

Camonsertib is an oral inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase that selectively targets and inhibits ATR activity and blocks the downstream phosphorylation of the serine ...