p27 (also known as KIP1, and encoded by CDKN1B) is regulated by multiple signal transduction pathways in normal and malignant cells. CDKN1B transcription can be regulated by the FoxO family and ...

Cambridge, Massachusetts-based biotech Regor Therapeutics Group has agreed to sell its portfolio of CDK inhibitors for the ... computer-accelerated drug discovery platform it calls CARD, has ...

Insilico Medicine Inc. has disclosed substituted thiazole compounds acting as cyclin-dependent kinase (CDK) inhibitors potentially useful for the treatment of cancer. Insilico Medicine identifies CDK2 ...

To this end, the company is “prioritizing further investment in its CDK franchise ... tyrosine kinase inhibitors. Blueprint has found success with Ayvakit, its FDA-approved drug for systemic ...