p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

it took some time for scientists to realize that all four papers described the same protein. Once everybody got on the same page, the community settled on a common name: p53. “The field looked at this ...

However, the hope for improved outcomes might be in the reactivation of the p53 protein, a key player in cancer suppression. The p53 protein, is a tumor suppressor often inactivated in cancers by ...

A kidney cancer cell nucleus is studded with aberrant nuclear speckles (orange). Normal healthy cells tend to have the speckles clustered toward the middle. Image credit: Kate Alexander (Cold Spring ...

Through a mechanism known as aberrant phase transition, mutant p53 induces amyloid aggregation in p63 and p73, forming harmful protein clumps known as amyloid structures. These aggregates drive ...

Kymera Therapeutics Inc. has published the characterization of KT-253, a novel compound designed to degrade the murine double minute 2 (MDM2) protein, offering a promising approach for cancers ...

Likewise, our findings demonstrate that wood smoke could produce similar effects on p53, phospho-p53, and MDM2 protein expression as tobacco.