The best-known of these is TP53 (producing the protein p53), discovered more than 40 years ago. Scientists certainly know a lot about p53. It starts a broad cascade of events inside the cell ...

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

Among their other tasks, members of the JDP family assist in the folding of the p53 protein, which is known as the "guardian ...

Kymera Therapeutics Inc. has published the characterization of KT-253, a novel compound designed to degrade the murine double minute 2 (MDM2) protein, offering a promising approach for cancers ...

Likewise, our findings demonstrate that wood smoke could produce similar effects on p53, phospho-p53, and MDM2 protein expression as tobacco.