Figure 1: Wild-type Ad5 generates cytopathic effect in cells expressing wild-type p53 but not in cells expressing mutant p53. These data indicate that p53 has a determining role in allowing ...

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical ...

In case of DNA damage, the p53 protein has the task of blocking the proliferation of the affected cell, thus providing extra time for repairs. Should this repair fail, the cell self-destructs and ...

A 58-year-old male patient presented to the dermatology clinic at West China Hospital of Sichuan University (Chengdu, Sichuan ...