Neurons that secrete the neuropeptide orexin help mice decide between exercise and snacking. I n neurobiologist Daria ...

This important study shows that the activity of hypothalamic hypocretin/orexin neurons (HONs) correlates with body movement over multiple behaviors. Sophisticated techniques and analyses showcase this ...

Hypocretin neurons activate brainstem 'REM-off' neurons ... many aspects of the circuitry of the hypocretin (also called orexin) system, which also influences hormone secretion and autonomic ...

Such neurons - for example orexin/hypocretin neurons - are increasingly implicated in disorders of energy balance, sleep, motor control, mood, and cognition. SELECTED RECENT PUBLICATIONS: Tesmer AL, ...

In a recent study published in the journal Nature Neuroscience, researchers investigate the role of hypocretin/orexin neurons (HONs) in temptation-resistant voluntary exercise (TRVE). Study ...

Orexin-A is a known sleep-related peptide secreted by specific neurons. Once released, orexin-A can activate many areas of the brain, because its receptors are distributed in various brain regions.

Trouble sleeping is common in other neurodegenerative diseases, but past research has only suggested that it occurs in ...

There seems to be a loss of orexin producing neurons in the brains of people with narcolepsy, suggesting agonists could strike at the underlying pathology of the condition. Orexin antagonists ...