Trouble sleeping is common in other neurodegenerative diseases, but past research has only suggested that it occurs in ...

In a recent study published in the journal Nature Neuroscience, researchers investigate the role of hypocretin/orexin neurons (HONs) in temptation-resistant voluntary exercise (TRVE). Study ...

There seems to be a loss of orexin producing neurons in the brains of people with narcolepsy, suggesting agonists could strike at the underlying pathology of the condition. Orexin antagonists ...

Another area of focus is the impact of aging on sleep stability. Research has shown that hyperexcitable hypocretin/orexin neurons contribute to sleep fragmentation in older adults. In aged mice ...

The orexinergic system originates within the hypothalamus and projects to multiple brain regions, including onto basal forebrain corticopetal cholinergic neurons. Our work has explored the role of the ...

Orexin-A is a known sleep-related peptide secreted by specific neurons. Once released, orexin-A can activate many areas of the brain, because its receptors are distributed in various brain regions.

Such neurons - for example orexin/hypocretin neurons - are increasingly implicated in disorders of energy balance, sleep, motor control, mood, and cognition. SELECTED RECENT PUBLICATIONS: Tesmer AL, ...