The aggregation of tau, leading to the formation of neurofibrillary tangles (NFTs), is likely to be associated with toxic gains-of-function. For example, NFTs may contribute to disease progression ...

涛蛋白最初或是防御机制 阿尔茨海默症患者的脑部会出现两种主要的病理特征：类淀粉斑（amyloid plaques）和涛蛋白（tau protein）形成的“神经纤维缠结”（neurofibrillary tangles）。涛蛋白在过去，通常被认为是有害的，然而这项新的研究却发现，涛蛋白最初可能是 ...

Drugs targeting amyloid plaques have failed to show efficacy in clinical trials. A new approach is needed to tackle AD ...

The possibility that Alzheimer’s disease diagnosis is associated with viruses, bacteria, fungi, and parasites has been ...

Despite decades of starts and stops, new treatments and key genetic discoveries are giving researchers great hope for slowing or eventually preventing Alzheimer’s disease.

Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is characterized by memory and physical impairment in aged individuals. microRNAs (miRNAs) are small, single-stranded noncoding ...

“In a discovery made here at UC Irvine and replicated in a lab at the National Institute on Aging, nicotinamide counteracted the neurofibrillary tangles of disease in mice ...

According to the Alzheimer’s Association ( there are currently 6.5 million people with Alzheimer’s disease. An estimated 6.9 ...

Another protein, hyperphosphorylated tau (pTau), also accumulates as toxic neurofibrillary tangles. Together, amyloid-β plaques and pTau tangles result in brain damage, neuroinflammation and ...