U-II was found to increase afterload and reduce myocardial contractility. Its effect at high concentrations is best rationalized by myocardial ischemia. Using the calculations of Sunagawa et al.

Specifically, before revascularization, 804 of 2,093 myocardial segments analyzed (38%) had abnormal contractility, and 694 segments (33%) had some areas of hyperenhancement. Among all 804 ...

[11] Beta blockers, including carvedilol, also decrease heart rate, myocardial contractility, and myocardial oxygen demand. Carvedilol also decreases systemic vascular resistance via its a ...

EHM allografts restore heart muscle safely, offering a breakthrough in heart failure treatment with no arrhythmia risk.

After a myocardial infarction, scarring and fibrosis of the LV wall leads to thinning, thereby increasing wall stress. Contractility: Contractility is the force of systolic contraction.