In a recent study published in Nature Genetics, researchers investigated the association of rare genetic variants with type 2 diabetes, focusing on the variants associated with monogenic diabetes.

In contrast, monogenic (mendelian) forms of hypertension are caused by single gene mutations that are influenced little, if at all, by environmental factors. Most monogenic forms of hypertension ...

comprises a group of monogenic diabetes arising from pathogenic variants (or mutations) in one of known MODY genes. Glucokinase-MODY and HNF1A-MODY are the two most common subtypes of MODY. A mild ...

Competing Interests: The authors declared no competing interests. Monogenic hypertension is caused by single gene mutations and accounts for a spectrum of familial forms of elevated blood pressure ...

A key challenge faced by both science and medicine has been to address the source of disease-causing mutations in multiple ... for the treatment of rare monogenic diseases in particular—one ...