Many questions and challenges exist for this burgeoning area of biology: What is the role of microenvironment in tissue specificity and is tissue specificity lost during disease progression? How does ...

Advances in single-cell biology have enabled the acquisition of detailed information at the single-cell level. The future challenge lies in elucidating the principles governing the interactions ...

Since the application of molecular biology in cancer biology ... Surrounding these epithelial cells is a microenvironment of supporting cells including stromal cells, such as lung fibroblasts ...

The Cancer Biology and Genetics (CBG) Program is on a quest to catalyze mechanism-driven ... Our multidisciplinary approach spans areas such as tumor progression and metastasis, tumor microenvironment ...

The cancer microenvironment, or tumour microenvironment, describes the non-cancerous cells present in the tumour. These include fibroblasts, immune cells and cells that comprise the blood vessels.

oncologists acknowledge that a deeper understanding of the location and interaction of immune-cell subpopulations within the tumour microenvironment (TME) is crucial to guide the development of ...

Research Areas: Cancer Pathobiology & Immunology, Cancer Genomics, Metabolomics, & Epigenetics, Carcinogenesis & Tumor Microenvironment, Metastasis & Experimental Therapeutics, Cancer Cell Biology & ...

An immuno-oncology targeting panel accurately characterized tumor-resident immune cells and located pathologically and clinically relevant tumor microenvironment features. Cancer development and ...

However, the effectiveness of these therapies often depends on a functional immune microenvironment in MM patients. Researchers from VIB and VUB now provide an interactive tool, based on a single ...

The Mara Sherman lab aims to understand the heterocellular interactions among pancreatic cancer cells and their surrounding microenvironment, and to target these networks for therapeutic benefit. Our ...