Nature11 个月
The exploration of macrocycles for drug discovery — an underexploited structural class
The modification of the ribosomal tunnel is conceptually similar to macrocycle-based modification of a protein–protein interaction surface. It is distinct from the enzymatic reaction inhibition ...
Business Wire1 个月
Circle Pharma Presents Promising Preclinical Data on First-in-Class Oral Macrocycle Cyclin ...
About CID-078, Circle Pharma’s Cyclin A/B RxL Inhibitor Program CID-078 is an orally bioavailable macrocycle with dual cyclin A and B RxL inhibitory activity that selectively targets tumor cells ...