Nature3 年
The first FDA approved treatment for ultra-rare endocrine tumors
which enabled them to generate high-specific activity (HSA)-MIBG 6. This formulation can deliver 100–200-fold higher levels of radiation to tumor cells at lower overall doses, resulting in a ...
Nature3 年
First FDA-approved treatment for an ultra-rare disease
After I-131 MIBG binds to its target and is internalized, the emitted radiation causes DNA damage and leads to cancer cell death. Early manufacturing processes for I-131 MIBG preparations were ...