The approach begins with expression of the target in cell lines, followed by assays to understand the kinetic intracellular signaling of the target (Fig. 1). The next step is to generate a ...

Researchers now offer a simplified method they call ProteinReDiff that uses artificial intelligence to speed the redesign of ligand-binding ... including cell signaling and enzymatic action.

The ability to alter proteins to refine control over binding affinity and specificity can create tailored therapeutics with reduced side effects, highly sensitive diagnostic tools, efficient ...

Innovative designs of GPCRs with enhanced signaling and stability offer new insights for drug discovery and synthetic biology ...

Researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel drug ...

EPFL researchers have developed a computational method to explicitly consider the impact of water while designing membrane ...

Researchers at the University of Sevilla in Spain have fabricated a ligand-free solar cell based on colloidal perovskite quantum dots (CPDTs) that has shown a power conversion efficiency of 9.3% ...