The Nmu gene was targeted for deletion by standard techniques (Supplementary Fig. 1 online). Nmu-/-mice were generated on a BL6/129 mixed background and backcrossed four times into C57BL/6J mice.

Reiko Hanada; Hitoshi Teranishi; James Todd Pearson; Mamoru Kurokawa; Hiroshi Hosoda; Nobuhiro Fukushima; Yoshihiko Fukue; Ryota Serino; Hiroaki Fujihara; Yoichi Ueta ...

A diabetes drug may beat costly shots for patients with a rare genetic condition, according to a Rutgers Health study.

The hypothalamus sits at the crossroads of nutritional signal input and feeding behavior output. This part of the brain can take signals from hormones such as leptin and translate them into ...

Discover how tirzepatide, a diabetes drug, offers hope for congenital generalized lipodystrophy (CGL) treatment, potentially ...

Higher levels of leptin, a hormone that helps maintain normal body weight, is associated with better signal-transmitting ... genetic and metabolic pathways. And the study of adipose or fatty ...

While both tirzepatide and leptin work in the brain, they do so through different signaling pathways, acting on different neurons in distinct brain regions. This suggests that leptin and GLP1 ...

While both tirzepatide and leptin work in the brain, they do so through different signaling pathways, acting on different neurons in distinct brain regions. This suggests that leptin and GLP1 ...